The ultimate goal of endodontic treatment is either to prevent the development of apical periodontitis or to create adequate conditions for periradicular tissue healing. This book provides effective treatment options for achieving both goals. The first section of the book details the microbiologic and pathophysiologic aspects of apical periodontitis. The second section focuses on the principles and practice of predictable endodontic treatment and the prevention of apical periodontitis. In this way, a thorough understanding of disease etiology, pathogenesis, and host-pathogen interaction issues sets the groundwork for effective endodontic treatment.